The rationale to design this innovative hand splint results from a recently developed maneuvre capable to ease or abolish paresthesias and pain in patients with CTS (Manente et al., in press 1999). This maneuvre suggests that the maintaining of a posture that squeezes the distal heads of metacarpal bones (excluding the first) and stretches the III and IV finger could be useful in conservative treatment of CTS. For this purpose we developed a splint (patent pending) made of the following components: 1) an inelastic belt with a velcro-adjustable closure positioned at the level of distal heads of metacarpal bones, 2) a triangular shaped pad, made of soft material, positioned dorsally to the II and V finger producing a mild stretching of III and IV finger, 3) an elastic wrist band with a velcro adjustable closure, 4) a dorsal hand stand stabilizing the components 1 and 2 connected by an adjustable string, to the component 3. Although this splint does not impede 1) the movement of thumb, 2) the opposition between thumb and other fingers, 3) the wrist flexion and extention, we suggest it only for nocturnal use. A study is in progress to assess the efficacy and tolerability of this innovative splint.